We’re officially hitting the home stretch of the college basketball betting action as March Madness rolls into the Elite Eight with a pair of regional finals Saturday.

No. 5 Houston is a -2.5 favorite over No. 2 Villanova for the first matchup in San Antonio. We’ve also got No. 2 Duke taking on No. 4 Arkansas, with the Blue Devils favored by -3.5.

Saturday’s College Basketball Betting Lines To Back

Houston -2.5 over Villanova

We’re not at all surprised to see the Cougars back in this spot for the second year in a row. Houston is so good on both ends of the floor and proved it yet again in a dominant 72-60 win over Arizona Thursday.

Things probably won’t go much better for Villanova today – there’s nothing the Wildcats do better than Houston and both teams prefer to play at the same pace. The Cougars have the momentum and the look of a team that’s ready to steamroll their way to another Final Four. We’re on Houston -2.5.

Duke -3.5 over Arkansas

This should be a track meet with two teams that love to push it in transition. Arkansas has one of the best backcourts in the country and Duke has the size and reach advantage in the paint. The Razorbacks guards do a great job around the rim and they were able to handle Gonzaga’s NBA big men in the Sweet 16 upset win.

The Blue Devils will be a tougher out. This is a battle-tested team that’s faced plenty of adversity and dealt with distractions all season. Now they’re playing their best ball of the year and should get past the Razorbacks to keep the dream of a Final Four rematch with North Carolina alive. We’re on Duke -3.5.

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The first two rounds of the NCAA Tournament are an in-your-face, nonstop magical mystery tour of college hoops from noon to night that all blurs together into a mash-up of bad beats, buzzer-beater covers and upsets galore. But the second weekend of the NCAA Tournament is a real sweet spot for college basketball betting.

The Sweet 16 gives us more time to focus on four matchups per day, and they’re all fascinating at this point in the bracket. With four games set for Thursday’s third round, there’s a few plays we’ve got our eyes on.

The action tips off at 7:09 p.m. with No. 1 Gonzaga a -9.5 favorite over No. 4 Arkansas. We’re also paying close attention to No. 3 Texas Tech as a -1 favorite over No. 2 Duke and No. 1 Arizona as a -1.5 favorite over No. 5 Houston.

Thursday's College Basketball Betting Lines To Back

Arkansas +9.5 over Gonzaga

The Razorbacks didn’t change many opinions with close wins over Vermont and New Mexico State. Arkansas still isn’t viewed as a serious contender despite last year’s Elite Eight run and an impressive SEC resume. Ugly wins or not, the Razorbacks are now 5-1 in their last six NCAA Tournament games with a lone loss to the champion Baylor Bears in 2021.

Gonzaga had problems of its own over the weekend, with Georgia State keeping it too close for comfort in the early going and Memphis grabbing a 10-point halftime lead. The defensive effort has slipped at times. That’s one of the reasons they went 0-2 against the spread in the opening rounds and have covered in just two of their last seven games. Arkansas has experienced, senior guards who can slow it down when needed, run the show and keep everyone composed. This could be a closer game than many expect. We’re on Arkansas +9.5.

Duke +1 over Texas Tech

This is a tough matchup for the Blue Devils. Texas Tech continues to defend at an elite level and the Red Raiders completely shut down a red-hot Notre Dame team in a 59-53 second-round win. They can impose their will on most teams in the country, but they have struggled against elite offensive teams with size and skill.

Texas Tech lost to Kansas twice and wasn’t close in a 69-55 loss to Gonzaga. Mike Krzyzewski has passed this test before, beating Texas Tech 69-58 in a nonconference matchup ahead of the Red Raiders’ National Championship appearance in 2019. The pieces are all there to do it again, with Duke rolling offensively and starting to look like a real title contender. We’re on Duke +1.

Houston +1.5 over Arizona

This has Game of the Week potential written all over it. No. 1 Arizona cruised into the second round before pulling through in an 85-80 overtime win against an upset-minded TCU. The Cougars might have been the most impressive team in the opening rounds all things considered, with an easy win over UAB and a no-drama 68-53 victory over a strong Illinois team.

Now Houston is two wins away from its second straight Final Four appearance, and the Cougars have every right to believe they’ll win this game. Houston is the better defensive team, plays at its own pace and has the pieces on offense to pull away. Arizona is more talented, but the Cougars are playing like the better team at the moment. We’re on Houston +1.5.

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